Activation of the NLRP3 inflammasome plays an important role in several neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, Huntington's disease,and spinocerebellar atrophy. Inhibition of inflammasome activation can slow the progression of neurodegenerative diseases. ALPS Biotech. has proved that the triterpenoid AL-126 from the fruiting body of Antrodia cinnamomea can inhibit the activation of NLRP3 inflammasome and significantly slow the disease progression in the mouse model of
Huntington's disease (US patent). ALPS Biotech. discovered new drugs for Huntington's disease (preclinical research stage), which will be applied to other neurodegenerative diseases in future.
